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- Title
Comparison of the Effectiveness of Pre-urodynamic Single-dose Levofloxacin with Post-urodynamic Levofloxacin for Three Days Related to the Incidence of Urinary Tract Infection: A Randomized Control Trial.
- Authors
Rahardjo, Harrina E.; Widia, Fina; Manurung, Mega Anara; Wicaksono, Indra; Soedarman, Soefiannagoya; Purwanto, Haryo Prakoso Adhi; Rizaly, Ahmad Aulia; Leonardo, Kevin; Afriansyah, Andika
- Abstract
<bold>Purpose: </bold>The current study aims to compare the effectiveness of pre-urodynamic single-dose levofloxacin and post-urodynamic levofloxacin for three days related to the incidence of urinary tract infections post-urodynamic examination.<bold>Materials and Methods: </bold>This is a single-blind randomized clinical trial conducted in three outpatient urology centers in Jakarta: Cipto Mangunkusumo General Hospital, Siloam Asri Hospital, and Persahabatan General Hospital using a consecutive sampling method between July 2019 - February 2022. The outcome of the study is the incidence of urinary tract infections in both treatment groups. Urinary tract infection was defined as a patient with one or more clinical symptoms of lower urinary tract infection and one or more urinalysis parameters positive for urinary tract infections. Chi-square was used to evaluate the association where p < 0.05 was used to determine statistical significance.<bold>Results: </bold>A total of 126 patients (63 patients in each arm) were included in the evaluation and analysis. Overall, urinary tract infections were detected in 25 cases (19.8%), 12 patients from the pre-urodynamic antibiotic group (9.5%) and 13 patients from the post-urodynamic antibiotic group (10.3%) (P = .823). E.coli was the most common bacteria found in the urine culture.<bold>Conclusion: </bold>There is no significant difference between a single dose of 500 mg of Levofloxacin administered one hour before the urodynamic study and a once-daily dose of 500 mg of Levofloxacin for three days following the urodynamic study related to urinary tract infections prevention post-urodynamic examination.
- Subjects
JAKARTA (Indonesia); URINARY tract infections; INFECTION control; INFECTION prevention; CLINICAL trials; HOSPITAL utilization
- Publication
Urology Journal, 2023, Vol 20, Issue 3, p167
- ISSN
1735-1308
- Publication type
Article
- DOI
10.22037/uj.v19i.7288