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- Title
The effect of hyperoxia on central blood pressure in healthy subjects.
- Authors
Siński, Maciej; Lewandowski, Jacek; Dobosiewicz, Anna; Przybylski, Jacek; Abramczyk, Piotr; Gaciong, Zbigniew
- Abstract
<bold>Introduction: </bold>Hyperoxia increases total peripheral resistance by acting locally but also inhibits the activity of carotid body chemoreceptors. We studied the effect of hyperoxia on central pressure in normotensive subjects.<bold>Material and Methods: </bold>Medical air followed by 100% oxygen was provided to 19 subjects (12/7 female/male, age 28.2 ±1.1 years) for 15 min through a non-rebreather mask. Central blood pressure was then measured using applanation tonometry.<bold>Results: </bold>After the first 2 min of hyperoxia, heart rate decreased significantly (65 ±2.6 beats/min vs. 61 ±2.1 beats/min, p = 0.0002). Peripheral and central blood pressure remained unchanged, while hemoglobin oxygen saturation and subendocardial viability ratio index increased (97 ±0.4% vs. 99 ±0.2%, p = 0.03; 168 ±8.4% vs. 180 ±8.2%, p = 0.009). After 15 min of 100% oxygen ventilation, heart rate and peripheral and central blood pressures remained unchanged from the first 2 min. The augmentation index, augmentation pressure and ejection duration increased as compared to baseline values and those obtained at 2 min (-5.1 ±2.9% vs. -1.2 ±2.6%, p = 0.005 and -4.6 ±2.7% vs. -1.2 ±2.6%, p = 0.0015; -1.3 ±0.7 mm Hg vs. -0.2 ±1.2 mm Hg, p = 0.003 and -1.1 ±0.7 mm Hg vs. -0.2 ±1.2 mm Hg, p = 0.012; 323 ±3.6 ms vs. 330 ±3.5 ms, p = 0.0002 and 326 ±3.5 ms vs. 330 ±3.5 ms, p = 0.021, respectively).<bold>Conclusions: </bold>The present study shows that hyperoxia does not affect central blood pressure in young healthy subjects and may improve myocardial blood supply estimated indirectly from applanation tonometry.
- Subjects
HYPEROXIA; BLOOD pressure; CAROTID body; HEMOGLOBINS; HEART beat; PHYSIOLOGY
- Publication
Archives of Medical Science, 2016, Vol 12, Issue 5, p992
- ISSN
1734-1922
- Publication type
journal article
- DOI
10.5114/aoms.2015.49038