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- Title
Accelerated Fractionated Radiation Therapy for Localized Glottic Carcinoma.
- Authors
Mizukami, Tatsuji; Yamagishi, Kentaro; Tobikawa, Masaki; Nakazato, Akira; Abe, Hideharu; Morita, Yuka; Saitoh, Jun-ichi
- Abstract
Background: The aim of this study is to examine the outcomes of an accelerated fractionated irradiation for N0 glottic carcinoma. Methods: In this retrospective analysis, 29 patients with N0 glottic carcinoma treated by radiation therapy were enrolled. Thirteen patients had T1a disease, six had T1b disease, and ten had T2 disease. A fractional dose of 2.1 Gy was administered to seven patients. The total doses were 65.1 and 67.2 Gy in four and three patients, respectively. A fractional dose of 2.25 Gy was administered to 22 patients. The total doses were 63 and 67.5 Gy in 21 patients and 1 patient with T2 disease, respectively. Additionally, 13 patients underwent the use of TS-1 (80–100 mg per day). Results: The median follow-up period was 33 months, and the 3-year local control rate was 95.6%. No patient had a lymph node or distant recurrence. As acute adverse events, grades 2 and 3 dermatitis were observed in 18 patients and 1 patient, and grades 2 and 3 mucositis were observed in 15 patients and 1 patient. As a late adverse event, one patient required tracheotomy because of laryngeal edema occurring. Conclusions: Accelerated fractionated irradiation may be an option in the radiation therapy of N0 glottic carcinoma because of its ability to shorten the treatment time.
- Subjects
RADIOTHERAPY; CARCINOMA; LYMPH nodes; TRACHEOTOMY
- Publication
Current Oncology, 2024, Vol 31, Issue 5, p2636
- ISSN
1198-0052
- Publication type
Article
- DOI
10.3390/curroncol31050198