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- Title
Oligopeptide/Histidine Transporter PHT1 and PHT2 — Function, Regulation, and Pathophysiological Implications Specifically in Immunoregulation.
- Authors
Dong, Minlei; Li, Ping; Luo, Jun; Chen, Binxin; Jiang, Huidi
- Abstract
The oligopeptide/histidine transporters PHT1 and PHT2, two mammalian solute carrier family 15A proteins, mediate the transmembrane transport of histidine and some di/tripeptides via proton gradient. PHT1 and PHT2 are distributed in a variety of tissues but are preferentially expressed in immune cells and localize to the lysosome-related organelles. Studies have reported the relationships between PHT1/PHT2 and immune diseases. PHT1 and PHT2 participate in the regulation of lysosomal homeostasis and lysosome-associated signaling pathways through their transport and nontransport functions, playing important roles in inflammatory diseases. In this review, we summarize recent research on PHT1 and PHT2, aiming to provide reference for their further biological research and as targets for drug design.
- Subjects
HISTIDINE; IMMUNOREGULATION; DRUG design; OLIGOPEPTIDES; TRIPEPTIDES; IMMUNOLOGIC diseases
- Publication
Pharmaceutical Research, 2023, Vol 40, Issue 11, p2585
- ISSN
0724-8741
- Publication type
Article
- DOI
10.1007/s11095-023-03589-8