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- Title
Coccygeal chordoma in a degu: case report and review of the literature.
- Authors
Sautier, Lucile; Guillier, David; Coste, Margaux; Servely, Jean-Luc; Pignon, Charly; Laloy, Eve; Donnelly, Thomas M.
- Abstract
An 8-y-old, intact female degu (Octodon degus) was presented with a slow-growing mass on the tail tip. The mass was completely removed by partial caudectomy. Histologically, the last coccygeal vertebra was replaced by a lobulated neoplasm composed of large clear polygonal cells embedded in a myxoid alcian blue–positive matrix with highly vacuolated cytoplasm (physaliferous cells) and intracytoplasmic periodic acid-Schiff–positive granules. The neoplasm exhibited the morphologic features of a "classic" chordoma of humans, which is 1 of 3 distinct chordoma subtypes. Immunohistochemistry revealed dual expression of cytokeratin AE1/AE3 and vimentin, consistent with a diagnosis of chordoma. Chordomas are uncommon slow-growing neoplasms in humans and animals, arising from notochordal remnants. Depending on their subtype and location, they can have a high local recurrence rate and metastatic risk. Chordoma should be included in the differential diagnosis of a soft tissue mass on the tail of a degu, similar to the clinical situation in ferrets.
- Subjects
DEGUS; CHORDOMA; TUMORS in animals
- Publication
Journal of Veterinary Diagnostic Investigation, 2019, Vol 31, Issue 1, p142
- ISSN
1040-6387
- Publication type
Case Study
- DOI
10.1177/1040638718814584