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- Title
Endodermal sinus (yolk sac) tumour of the liver. A case report and review of the literature.
- Authors
Narita, Takeo; Moriyama, Yuzo; Ito, Yasuo
- Abstract
A primary endodermal sinus tumour of the liver which developed in a 27-year-old woman is reported. The dimensions of the tumour were 11 × 11 × 9·5 cm. Most parts were friable, haemorrhagic, and necrotic. No metastasis was found, but one part of the tumour was invading the diaphragm directly. Histologically, the tumour had mainly a reticular pattern, and partly a solid pattern, and was characterized by the presence of Schiller-Duval bodies and intra-and extracellular hyaline globules. A small part of the tumour showed a polyvesicular vitelline pattern and glandular structures with enteric differentiation. Serum alpha-fetoprotein was very high (28 500 ng/ml), but carcinoembryonic antigen was within the normal range. Immunohistochemically, most of the tumour cells contained alpha-fetoprotein and alpha-1-antitrypsin. Carcinoembryonic antigen and glutathione S-transferase, which was recently proved to be a useful marker for colonic carcinoma, were detected only in the glandular part. Four previously reported cases of primary endodermal sinus tumour of the liver are reviewed.
- Publication
Journal of Pathology, 1988, Vol 155, Issue 1, p41
- ISSN
0022-3417
- Publication type
Article
- DOI
10.1002/path.1711550108