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- Title
Expression of the estrogen receptor and type II collagen in the mandibular condylar cartilage of the human embryo.
- Authors
Zhang Yuerong; Pang Lei; Liu Zhonglin
- Abstract
Objective To study the expression of the estrogen receptor (ER) and type II collagen in the mandibular condylar cartilage of the human embryo. Methods The expression and localization of ERa, ER0, and type II collagen in the mandibular condylar cartilage of the human embryo were examined through hematoxylin-eosin (HE) and immunohistoche-mistry staining. Results Type H collagen was primarily localized in the transitional and hypertrophic layers of the condylar cartilage. ERa was mostly expressed in the transitional and hypertrophic cartilaginous layers of the condylar cartilage. ERa was evenly distributed in the cell, whereas ER0 was localized in the nuclei. No expression of type II collagen and ER was found in the fibrage and the proliferative layer although minimal expression was found in the calcified cartilage. Conclusion The distribution of ER and type II collagen in the mandibular condylar cartilage was consistent. Estrogen can selectively combine with different subtypes of ER that regulate the ability of the condylar cartilage cells to secrete type II collagens.
- Subjects
ESTROGEN receptors; HUMAN embryos; COLLAGEN; CARTILAGE; IMMUNOHISTOCHEMISTRY
- Publication
West China Journal of Stomatology, 2013, Vol 31, Issue 5, p526
- ISSN
1000-1182
- Publication type
Article
- DOI
10.7518/hxkq.2013.05.020