We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
HDAC4 blocks autophagy to trigger podocyte injury: non-epigenetic action in diabetic nephropathy.
- Authors
Wei, Qingqing; Dong, Zheng
- Abstract
Histone deacetylases (HDACs) have been implicated in the pathogenesis of kidney diseases including diabetic nephropathy (DN); however, the mechanism is poorly understood. Wang et al. unravel the changes in expression of various HDACs in DN and demonstrate that HDAC4 specifically contributes to podocyte injury in DN. HDAC4 deacetylates STAT1 to suppress autophagy, an essential cellular process for the function and viability of podocytes. The development of HDAC isoform-specific inhibitors may provide efficacious therapeutics for DN and related renal diseases.
- Subjects
HISTONE deacetylase; DIABETIC nephropathies; STREPTOZOTOCIN; HYPERGLYCEMIA; PHOSPHORYLATION; CELL proliferation
- Publication
Kidney International, 2014, Vol 86, Issue 4, p666
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1038/ki.2014.142