We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
An Intensive, Active Surveillance Reveals Continuous Invasion and High Diversity of Rhinovirus in Households.
- Authors
Kamau, Everlyn; Onyango, Clayton O; Otieno, Grieven P; Kiyuka, Patience K; Agoti, Charles N; Medley, Graham F; Cane, Patricia A; Nokes, D James; Munywoki, Patrick K
- Abstract
We report on infection patterns in 5 households (78 participants) delineating the natural history of human rhinovirus (HRV). Nasopharyngeal collections were obtained every 3–4 days irrespective of symptoms, over a 6-month period, with molecular screening for HRV and typing by sequencing VP4/VP2 junction. Overall, 311/3468 (8.9%) collections were HRV positive: 256 were classified into 3 species: 104 (40.6%) HRV-A; 14 (5.5%) HRV-B, and 138 (53.9%) HRV-C. Twenty-six known HRV types (13 HRV-A, 3 HRV-B, and 10 HRV-C) were identified (A75, C1, and C35 being most frequent). We observed continuous invasion and temporal clustering of HRV types in households (range 5–13 over 6 months). Intrahousehold transmission was independent of clinical status but influenced by age. Most (89.0%) of HRV infection episodes were limited to <14 days. Individual repeat infections were frequent (range 1–7 over 6 months), decreasing with age, and almost invariably heterotypic, indicative of lasting type-specific immunity and low cross-type protection.
- Subjects
KENYA; RHINOVIRUSES; HOUSEHOLDS
- Publication
Journal of Infectious Diseases, 2019, Vol 219, Issue 7, p1049
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/jiy621