We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Higher Prevalence of Frailty Among a Sample of HIV-Infected Middle-aged and Older Chinese Adults Is Associated With Neurocognitive Impairment and Depressive Symptoms.
- Authors
Yingying Ding; Haijiang Lin; Xing Liu; Wong, Frank Y.; Sun, Yan V.; Marconi, Vincent C.; Na He; Ding, Yingying; Lin, Haijiang; Liu, Xing; He, Na
- Abstract
We investigated the prevalence and correlates of prefrailty/frailty, determined on the basis of the Fried criteria, in Chinese patients with and those without human immunodeficiency virus (HIV) infection. HIV-infected patients were more likely to be frail or prefrail than controls, and this association remained significant after adjustment for potential confounders (odds ratio, 3.79). After additional adjustment for neurocognitive impairment and depressive and insomnia symptoms, this association remained significant but attenuated (odds ratio, 2.16). In the HIV-infected group, these 3 variables were independently associated with prefrailty/frailty. These findings suggest that neurocognitive impairment and depressive and/or insomnia symptoms may account for a higher prevalence of prefrailty/frailty in HIV-infected patients but require further longitudinal investigation.
- Subjects
FRAGILITY (Psychology); PSYCHOLOGY of HIV-positive persons; DISEASE prevalence; COGNITION disorders; MENTAL depression; HEALTH of adults
- Publication
Journal of Infectious Diseases, 2017, Vol 215, Issue 5, p687
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jix032