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- Title
A Newly Emerged Swine-Origin Influenza A(H3N2) Variant Dampens Host Antiviral Immunity but Induces Potent Inflammasome Activation.
- Authors
Weiping Cao; Mishina, Margarita; Ranjan, Priya; De La Cruz, Juan A.; Jin Hyang Kim; Garten, Rebecca; Kumar, Amrita; García-Sastre, Adolfo; Katz, Jacqueline M.; Gangappa, Shivaprakash; Sambhara, Suryaprakash; Cao, Weiping; Kim, Jin Hyang
- Abstract
We compared the innate immune response to a newly emerged swine-origin influenza A(H3N2) variant containing the M gene from 2009 pandemic influenza A(H1N1), termed "A(H3N2)vpM," to the immune responses to the 2010 swine-origin influenza A(H3N2) variant and seasonal influenza A(H3N2). Our results demonstrated that A(H3N2)vpM-induced myeloid dendritic cells secreted significantly lower levels of type I interferon (IFN) but produced significantly higher levels of proinflammatory cytokines and induced potent inflammasome activation. The reduction in antiviral immunity with increased inflammatory responses upon A(H3N2)vpM infection suggest that these viruses have the potential for increased disease severity in susceptible hosts.
- Subjects
INFLUENZA A virus, H3N2 subtype; ANTIVIRAL agents; IMMUNITY; INFLAMMASOMES; DENDRITIC cells; CYTOKINES; SWINE; INFLAMMATION; PROTEIN metabolism; ANIMAL experimentation; CELL lines; RESEARCH funding; INFLUENZA A virus, H1N1 subtype; MONONUCLEAR leukocytes; ORTHOMYXOVIRUS infections
- Publication
Journal of Infectious Diseases, 2015, Vol 212, Issue 12, p1923
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiv330