We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Sentinel Node Biopsy in Special Histologic Types of Invasive Breast Cancer.
- Authors
Solà, Montserrat; Recaj, Mireia; Castellà, Eva; Puig, Pere; Gubern, Josep Maria; Julian, Juan Francisco; Fraile, Manel
- Abstract
Objective: To assess the feasibility of sentinel node biopsy (SNB) in ductal and lobular invasive breast cancer, a group of tumors known as special histologic type (SHT) of breast cancer. Materials and Methods: Between January 1997 and July 2008, 2253 patients from 6 affiliated hospitals underwent SNB who had early breast cancer and clinically negative axilla. The patients' data were collected in a multicenter database. For lymphatic mapping, all patients received an intralesional dose of radiocolloid Tc-99m (4mCi in 0.4 mL saline), at least two hours before the surgical procedure. SNB was performed by physicians from the same nuclear medicine department in all cases. Results: Of the 2253 patients in the database, the SN identification rate was 94.5% (no radiotracer migration in 123 patients), and positive sentinel node prevalence was 22%. SHT was reported in 144 patients (6.4%) of the whole series. In this subgroup, migration of radiotracer was unsuccessful in 8 patients (identification rate was 94.4%) and SNs were positive in 7.4%. SN positivity prevalence in these tumors was variable across the subtypes. Higher probability of lymphatic spread seemed to be related to tumor invasiveness (20% of positivity in micropapillary, 15% in cribriform subtypes, and 0% in adenoid-cystic). Conclusion: Sentinel node biopsy is feasible in special histologic subtypes of breast carcinoma with a good identification rate. Lower migration rates, however, might be associated with special histologic features (colloid subtype). Complete axillary dissection after a positive sentinel node cannot be omitted in patients with SHT breast cancer because they can be associated with further axillary disease; the reported very low incidence of axillary metastases would justify avoiding axillary dissection only in the adenoid-cystic subtype.
- Subjects
BREAST cancer surgery; HISTOLOGY; CANCER invasiveness; MEDICAL databases; BREAST cancer patients; RADIOCOLLOIDS; RADIOACTIVE tracers
- Publication
Meme Sagligi Dergisi / Journal of Breast Health, 2016, Vol 12, Issue 2, p78
- ISSN
1306-0945
- Publication type
Article
- DOI
10.5152/tjbh.2016.2929