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- Title
Faster Progression to AIDS and AIDS-Related Death Among Seroincident Individuals Infected With Recombinant HIV-1 A3/CRF02_AG Compared With Sub-subtype A3.
- Authors
Palm, Angelica A.; Esbjörnsson, Joakim; Månsson, Fredrik; Kvist, Anders; Isberg, Per-Erik; Biague, Antonio; da Silva, Zacarias José; Jansson, Marianne; Norrgren, Hans; Medstrand, Patrik
- Abstract
Background. Human immunodeficiency virus type 1 (HIV-1) is divided into subtypes and circulating recombinant forms (CRFs) but the impact of subtype/CRF on disease progression is not fully understood.Methods. We determined the HIV-1 subtype/CRF of 152 seroincident individuals from Guinea-Bissau, based on the C2–V3 region of env. Disease progression was measured as time from estimated seroconversion to AIDS and AIDS-related death. Hazard ratios (HRs) were calculated using a Cox proportional hazard model, adjusting for gender and age at seroconversion.Results. The major subtypes/CRFs identified were CRF02_AG (53%), A3 (29%), and A3/02 (a recombinant of A3 and CRF02_AG) (13%). Infection with A3/02 was associated with a close to 3-fold increased risk of AIDS and AIDS-related death compared to A3 (HR = 2.6 [P = 0.011] and 2.9 [P = 0.032], respectively). The estimated time from seroconversion to AIDS and AIDS-related death was 5.0 and 8.0 years for A3/02, 6.2 and 9.0 years for CRF02_AG, and 7.2 and 11.3 years for A3.Conclusion. Our results show that there are differences in disease progression between HIV-1 A-like subtypes/CRFs. Individuals infected with A3/02 have among the fastest progression rates to AIDS reported to date. Determining the HIV-1 subtype of infected individuals could be important in the management of HIV-1 infections.
- Subjects
WEST Africa; HIV-1 glycoprotein 120; DISEASE progression; MORTALITY; GENDER; AGE
- Publication
Journal of Infectious Diseases, 2014, Vol 209, Issue 5, p721
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/jit416