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- Title
Niedobór witaminy D u chorych na toczeń rumieniowaty układowy.
- Authors
Bogaczewicz, Jarosław; Sysa-Jędrzejowska, Anna; Arkuszewska, Cecylia; Hawro, Tomasz; Karczmarewicz, Elżbieta; Lorenc, Roman S.; Płudowski, Paweł; Ząbek, Jakub; Woźniacka, Anna
- Abstract
Introduction: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects skin and internal organs. As the disease tend to be flared and/or exacerbated by ultraviolet radiation, photoprotection is recommended management. Objective: To investigate serum concentration of 25(OH) vitamin D3 in patients with SLE, and assess association between vitamin D level and demographic, constitutional as well as habitual variables and pharmacotherapy. Material and methods: The study covered 32 patients with SLE (29 females and 3 males) who completed questionnaire assessing demographic data along with methods of photoprotection, and underwent clinical examination followed by routine laboratory tests. SLE activity was evaluated with SLAM score. Serum concentration of 25(OH) vitamin D3 was measured with automated electrochemiluminescence. Multiple regression procedures were used in order to find the predictor of serum concentration of 25(OH) vitamin D3, among clinical findings, demographic variables, and methods of photoprotection. Results: In entire group of SLE patients serum concentration of 25(OH) vitamin D3 (9.62±5.77 ng/ml) was lower than recommended level (<30 ng/ml). Vitamin D3 deficit (<10 ng/ml) was found in 18 (56.25%) patients, deficiency (10-20 ng/ml) in 12 (37.5%), and hypovitaminosis (20-30 ng/ml) in 2 (6.25%). Sunscreen usage was found to be predictor of serum 25(OH) vitamin D3 concentration (Beta=-0,46; p=0.001). No association was found between serum 25(OH) vitamin D3 concentration and age, gender, body mass, height, BMI, skin phototype, disease duration, and pharmacotherapy. The disease activity was not correlated with serum 25(OH) vitamin D3 concentration. Conclusion: Obtained results show the vitamin D deficiency in patients with SLE, indicate association between deficiency and sunscreens usage, and emphasize the rationale for prevention of metabolic complications resulting from vitamin D deficiency.
- Subjects
VITAMIN D deficiency; VITAMIN deficiency; OSTEOMALACIA; OSTEOPOROSIS; RICKETS; SYSTEMIC lupus erythematosus
- Publication
Clinical Dermatology / Dermatologia Kliniczna, 2008, Vol 10, Issue 3, p129
- ISSN
1730-7201
- Publication type
Article