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- Title
Apolipoprotein E protects astrocytes from hypoxia and glutamate-induced apoptosis
- Authors
Zhou, Shuai; Wu, Haitao; Zeng, Chun; Xiong, Xuehua; Tang, Shuang; Tang, Zhaohua; Sun, Xiaochuan
- Abstract
Abstract: Apolipoprotein E (apoE) is predominantly synthesized by astrocytes in the brain. In this study, we investigated the role of apoE in astrocyte apoptosis. We demonstrated that apoE protects astrocytes from hypoxia-induced apoptosis in a dose-dependent manner. Glutamate release from astrocytic cultures is significantly lower from WT mice than from apoE knockout mice. Furthermore, the protective effect of apoE is mimicked by an NMDA receptor antagonist, MK-801. Finally, the apoE activator T0901317 significantly reduced the effect of glutamate-induced apoptosis of astrocytes. These results suggest that apoE protects astrocytes from hypoxia-induced apoptosis associated to NMDA receptor activation. Approaches that elevate apoE secretion in astrocytes might provide a novel strategy in the protection of neuronal ischemic injury.
- Subjects
APOLIPOPROTEIN E; ASTROCYTES; HYPOXEMIA; GLUTAMIC acid; APOPTOSIS; KNOCKOUT mice; METHYL aspartate receptors
- Publication
FEBS Letters, 2013, Vol 587, Issue 2, p254
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2012.12.003