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- Title
Identification of a novel human MT5-MMP transcript variant in multipotent NT2 cells
- Authors
Ross, Heather H.; Fillmore, Helen L.
- Abstract
Abstract: Membrane-type 5 matrix metalloproteinase (MT5-MMP) expression is ubiquitous in brain development while restricted to regions of neuroplasticity in adult. In the multipotent NT2 model of neurogenesis and differentiation, MT5-MMP is differentially expressed with significantly higher mRNA levels in the differentiated neuronal hNT cells. MT5-MMP cDNA cloned from NT2 cells unexpectedly revealed a novel sequence (MT5-MMPvar) characterized by a 162bp deletion. Both transcripts were identified in NT2, hNT and adult human hippocampus. In vitro, MT5-MMPvar translated into a ∼55kDa protein. It was also detected in NT2, hNT and adult human hippocampus. These results suggest more than one human MT5-MMP transcript may exist in the central nervous system.
- Subjects
METALLOPROTEINASES; NERVOUS system; TRETINOIN; NEUROPLASTICITY
- Publication
FEBS Letters, 2007, Vol 581, Issue 30, p5923
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2007.11.074