We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
c-Src is a PDZ interaction partner and substrate of the E3 ubiquitin ligase Ligand-of-Numb protein X1
- Authors
Weiss, Andreas; Baumgartner, Martin; Radziwill, Gerald; Dennler, Julia; Moelling, Karin
- Abstract
Abstract: The very C-terminus of c-Src is a ligand for PDZ domains. In a screen for PDZ domains that interact with c-Src, we identified one of the PDZ domains of the Ligand-of-Numb protein X1 (LNX1), a multiple PDZ domain scaffold and RING type E3 ubiquitin ligase. We demonstrate that the interaction of c-Src with LNX1 depends on the C-terminal PDZ ligand of c-Src. Furthermore, we show that c-Src phosphorylates LNX1. Moreover, c-Src itself is ubiquitinated by LNX1, suggesting an interdependent regulation of c-Src and LNX1.
- Subjects
LIGANDS (Biochemistry); PROTEINS; CHEMICAL reactions; LIGASES
- Publication
FEBS Letters, 2007, Vol 581, Issue 26, p5131
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2007.09.062