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- Title
Angiotensin II induces tyrosine nitration and activation of ERK1/2 in vascular smooth muscle cells
- Authors
Pinzar, Elena; Wang, Tianyi; Garrido, Maria R.; Xu, Wei; Levy, Patrick; Bottari, Serge P.
- Abstract
Abstract: Angiotensin II (Ang II) induces a prominent and sustained nitration and activation of ERK1/2 in rat vascular smooth muscle cells, both mediated via AT1 receptor. Nitration and activation was also shown for recombinant non-activated extracellular signal-regulated kinase (ERK) and MEK. Nitration and phosphorylation of ERK1/2 by Ang II was significantly inhibited by NAD(P)H inhibitors and scavengers of oxygen and nitrogen reactive species and completely blocked by a selective inducible nitric-oxide synthase inhibitor. MEK inhibitor U0126 did not affect ERK nitration but completely blocked activation. These data indicate that Ang II nitrates and activates ERK1/2 via a reactive species-sensitive pathway.
- Subjects
SMOOTH muscle; VASCULAR smooth muscle; MUSCLE cells; ANGIOTENSINS
- Publication
FEBS Letters, 2005, Vol 579, Issue 22, p5100
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2005.08.019