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- Title
Differences in maternal and neonatal cardiometabolic markers and placenta status by foetal sex. The GESTAFIT project.
- Authors
Aparicio, Virginia A; Baena-García, Laura; Flor-Alemany, Marta; Martínez-González, Luis J; Varela-López, Alfonso; Sánchez, Cristina; Quiles, José L
- Abstract
Aims: To explore the differences in some maternal-neonatal metabolic markers and placenta status by foetal sex. Methods: One hundred thirty-nine Caucasian pregnant women from the GESTAFIT project and their new-borns were included in the present cross-sectional study. Serum cardiometabolic markers (i.e. lipid and glycaemic profile and uric acid) were analysed at late pregnancy and at birth. In placenta, telomeres length, proportion of deleted mitochondrial-DNA and mitochondrial-DNA density, some minerals and interleukin 8, epidermal growth factor, fibroblast growth factor-2 and vascular endothelial growth factor were measured. The study was run between November 2015 and April 2018. Results: Mothers carrying a male showed higher serum triglycerides than mothers carrying a female at late pregnancy (p <.05). Serum total and low-density lipoprotein cholesterol were greater in males' umbilical cord blood artery compared to females' new-borns (both, p <.05). Mothers of males and male new-borns presented higher uric acid than mothers of females and female new-borns at birth (p <.05). Female's placentas presented greater placental-newborn weight ratio, manganese content and fibroblast growth factor-2 (all, p ⩽.05), and evidence of statistical significance in telomeres length, which were 17% longer (p =.076). Conclusion: Our findings show weak differences in some cardiometabolic and placental status markers by foetal sex. Notwithstanding, we observed a slightly more proatherogenic profile in both, mothers carrying males' foetuses and male new-borns. We also found lower serum uric acid and better placenta status in mothers carrying a female. These findings indicate that foetal sex might need to be considered for a more personalized follow-up of pregnancies.
- Subjects
CARDIOVASCULAR diseases risk factors; BIOMARKERS; FIBROBLAST growth factors; TELOMERES; TRIGLYCERIDES; ANTHROPOMETRY; PREGNANT women; PLACENTA; DESCRIPTIVE statistics; RESEARCH funding; SEX determination; SOCIODEMOGRAPHIC factors; URIC acid; DATA analysis software; LIPIDS
- Publication
Women's Health (17455057), 2022, Vol 18, p1
- ISSN
1745-5057
- Publication type
Article
- DOI
10.1177/17455057221117976