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- Title
Influence of the Generator in-Growth Time on the Final Radiochemical Purity and Stability of <sup>99m</sup>Tc Radiopharmaceuticals.
- Authors
Uccelli, L.; Boschi, A.; Pasquali, M.; Duatti, A.; Di Domenico, G.; Pupillo, G.; Esposito, J.; Giganti, M.; Taibi, A.; Gambaccini, M.
- Abstract
At Legnaro laboratories of the Italian National Institute for Nuclear Physics (INFN), a feasibility study has started since 2011 related to accelerated-based direct production of 99mTc by the 100Mo(p,2n) 99mTc reaction. Both theoretical investigations and some recent preliminary irradiation tests on 100Mo-enriched samples have pointed out that both the 99gTc/ 99mTc ratio and the 99mTc specific activity will be basically different in the final accelerator-produced Tc with respect to generator-produced one, which might affect the radiopharmaceutical procedures. The aimof this work was to evaluate the possible impact of different 99gTc/99mTc isomeric ratios on the preparation of different Tc-labeled pharmaceutical kits. A set of measurements with 99mTc, eluted from a standard 99Mo/ 99mTc generator, was performed, and results on both radiochemical purity and stability studies (following the standard quality control procedures) are reported for a set of widely used pharmaceuticals (i.e., 99mTc-Sestamibi, 99mTc-ECD, 99mTc-MAG3, 99mTc-DTPA, 99mTc-MDP, 99mTc-HMDP, 99mTc-nanocolloids, and 99mTc-DMSA). These pharmaceuticals have been all reconstituted with either the first [ 99mTcO4]- eluate obtained from a 99Mo/ 99mTc generator (coming from two different companies) or eluates after 24, 36, 48, and 72 hours from last elution. Results show that the radiochemical purity and stability of these radiopharmaceuticals were not affected up to the value of 11.84 for the 99gTc/ 99mTc ratio.
- Subjects
NUCLEAR physics; RADIOPHARMACEUTICALS; MEDICAL radiology; PHARMACOLOGY; RADIOPHARMACOLOGY
- Publication
Science & Technology of Nuclear Installations, 2013, p1
- ISSN
1687-6075
- Publication type
Article
- DOI
10.1155/2013/379283