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- Title
Association of sets of alleles of genes encoding β<sub>3</sub>–adrenoreceptor, uncoupling protein 1 and lipoprotein lipase with increased risk of metabolic complications in obesity.
- Authors
Proenza, A M; Poissonnet, C M; Ozata, M; Ozen, S; Guran, S; Palou, A; Strosberg, A D
- Abstract
OBJECTIVE: To investigate the relationship between the polymorphisms of the β[sub 3]-AR (Trp64Arg), UCP1 (A→G) and LPL (HindIII and PvuII) loci and the metabolic complications associated with obesity in a Turkish population. SUBJECTS: 271 unrelated individuals of Turkish origin including obese (body mass index, BMI>30 kg/m²) and lean (BMI ≤25 kg/m²) subjects. MEASUREMENTS: Anthropometric (weight, height and blood pressure) and metabolic measurements (plasma levels of glucose, cholesterol and triglycerides), and determination of β[sub 3]-AR, UCP1 and LPL genotypes by polymerase chain reaction followed by enzymatic digestion. RESULTS: The distributions of genotypes for each candidate gene (β[sub 3]-AR, UCP1 and LPL) were similar between the obese and the lean subjects. The Arg[sup 64] allele of the β[sub 3]-AR gene was absent from massively obese men. GG carriers of the A→G variant of the UCP1 gene showed BMI-associated increases of cholesterol levels which were more marked than both AA (P=0.027) and AG (P=0.039) carriers. Obese P+ carriers of the LPL Pvull variant had significantly higher levels of glucose than non-carriers (P=0.011), whereas obese P+P+ carriers did not have significantly different levels of triglycerides than non-carriers (P=0.087). Moreover, carriers of both alleles (G&P+) had higher levels of glucose than non-carriers (P=0.048), but did not have significantly different levels of triglycerides than non-carriers (P=0.125). However, the BMI-associated increase of triglycerides of P+&G carriers was significantly more marked than that of P+ carriers (P=0.0085). CONCLUSION: Our data support the idea that alleles of specific genes (UCP1, LPL and β[sub 3]-AR) might play a role in the development of certain metabolic complications of obesity and might have additive effects when combined with each other (as in the case of UCP1 and LPL).
- Subjects
TURKEY; BETA adrenoceptors; LIPOPROTEIN lipase; OBESITY
- Publication
International Journal of Obesity & Related Metabolic Disorders, 2000, Vol 24, Issue 1, p93
- ISSN
0307-0565
- Publication type
Article
- DOI
10.1038/sj.ijo.0801091