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- Title
Randomized trial on protein vs carbohydrate in ad libitum fat reduced diet for the treatment of obesity.
- Authors
Skov, A R; Toubro, S; Rønn, B; Holm, L; Astrup, A
- Abstract
OBJECTIVE: To study the effect on weight loss in obese subjects by replacement of carbohydrate by protein in ad libitum consumed fat-reduced diets. DESIGN: Randomized dietary intervention study over six months comparing two ad libitum fat reduced diets (30% of total energy) strictly controlled in composition: High-carbohydrate (HC, protein 12% of total energy) or high-protein (HP, protein 25% of total energy). SETTING AND PARTICIPANTS: Subjects were 65 healthy, overweight and obese subjects (50 women, 15 men, aged 18–55 y) randomly assigned to HC (n=25), HP (n=25) or a control group (C, n=15). All food was provided by self-selection in a shop at the department, and compliance to the diet composition was evaluated by urinary nitrogen excretion. MAIN OUTCOME MEASURE: Change in body weight, body composition and blood lipids. RESULTS: More than 90% completed the trial. Weight loss after six months was 5.1 kg in the HC group and 8.9 kg in the HP group (difference 3.7 kg, 95% confidence interval (CI)(1.3–6.2 kg) P<0.001), and fat loss was 4.3 kg and 7.6 kg, respectively (difference 3.3 kg (1.1–5.5 kg) P<0.0001), whereas no changes occurred in the control group. More subjects lost >10 kg in the HP group (35 %) than in the HC group (9 %). The HP diet only decreased fasting plasma triglycerides and free fatty acids significantly. CONCLUSIONS: Replacement of some dietary carbohydrate by protein in an ad libitum fat-reduced diet, improves weight loss and increases the proportion of subjects achieving a clinically relevant weight loss. More freedom to choose between protein-rich and complex carbohydrate-rich foods may allow obese subjects to choose more lean meat and dairy products, and hence improve adherence to low-fat diets in weight reduction programs.
- Subjects
WEIGHT loss; DIET; OVERWEIGHT persons; OBESITY
- Publication
International Journal of Obesity & Related Metabolic Disorders, 1999, Vol 23, Issue 5, p528
- ISSN
0307-0565
- Publication type
Article
- DOI
10.1038/sj.ijo.0800867