The article focuses on a study that shows a link between metabolism disorders, heart failure, and sirtuins (SIRTs)-regulated genes. It informs that sirtuins (SIRTs) play a vital role in response to caloric restriction, and the regulation of aging and lifespan. It also informs that SIRTs, family of class III histone deacetylases (HDACs), can catalyze deacetylation of histone and nonhistone lysines.