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- Title
Marked prolongation of porcine renal xenograft survival in baboons through the use ofa1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue.
- Authors
Yamada, Kazuhiko; Yazawa, Koji; Shimizu, Akira; Iwanaga, Takehiro; Hisashi, Yosuke; Nuhn, Matthew; O'Malley, Patricia; Nobori, Shuji; Vagefi, Parsia A; Patience, Clive; Fishman, Jay; Cooper, David K C; Hawley, Robert J; Greenstein, Julia; Schuurman, Henk-Jan; Awwad, Michel; Sykes, Megan; Sachs, David H
- Abstract
The use of animal organs could potentially alleviate the critical worldwide shortage of donor organs for clinical transplantation. Because of the strong immune response to xenografts, success will probably depend upon new strategies of immune suppression and induction of tolerance. Here we report our initial results usinga-1,3-galactosyltransferase knockout (GalT-KO) donors and a tolerance induction approach. We have achieved life-supporting pig-to-baboon renal xenograft survivals of up to 83 d with normal creatinine levels.
- Subjects
XENOGRAFTS; TRANSPLANTATION of organs, tissues, etc.; ORGAN donation; IMMUNOSUPPRESSION; IMMUNOLOGY; IMMUNE response
- Publication
Nature Medicine, 2005, Vol 11, Issue 1, p32
- ISSN
1078-8956
- Publication type
Article
- DOI
10.1038/nm1172