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- Title
Decreases in Inflammatory and Coagulation Biomarkers Levels in HIV-Infected Patients Switching from Enfuvirtide to Raltegravir: ANRS 138 Substudy.
- Authors
Silva, Erika F.; Charreau, Isabelle; Gourmel, Bernard; Mourah, Samia; Kalidi, Issa; Guillon, Brigitte; De Castro, Nathalie; Caron, François; Braun, Josephine; Molina, Jean-Michel
- Abstract
Stored plasma specimens from 164 participants in the ANRS 138 trial were analyzed to determine interleukin 6 (IL-6), high-sensitivity C-reactive protein (hsCRP), and D-dimer levels at baseline and weeks 24 and 48. These virologically suppressed, treatment-experienced patients were randomly assigned to undergo an immediate switch (IS) or a deferred switch (DS; at week 24) from an enfuvirtide-based antiretroviral therapy (ART) regimen to a raltegravir-based regimen. At week 24, a significant decrease from baseline was observed in the IS arm, compared with the DS arm, for IL-6 level (−30% vs +10%; P < .002), hsCRP level (−46% vs +15%; P < .0001), and D-dimer level (−40% vs +6%; P < .0001). At week 48, there was a reproducible decrease in levels of all biomarkers in the DS arm.
- Subjects
RALTEGRAVIR; BIOMARKERS; HIV-positive persons; ENFUVIRTIDE (Drug); VIROLOGY; ANTIRETROVIRAL agents
- Publication
Journal of Infectious Diseases, 2013, Vol 208, Issue 6, p892
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/jit280