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- Title
The simultaneous occurrence of variant hairy cell leukemia and chronic-phase chronic myelogenous leukemia. A case report.
- Authors
Reeves, James E.; Robbins, Bruce A.; Pankey, Lee R.; Elias, Abdalla L.; Anderson, William F.; Reeves, J E; Robbins, B A; Pankey, L R; Elias, A L; Anderson, W F
- Abstract
<bold>Background: </bold>Coexistence of second malignancies in patients with hairy cell leukemia is not uncommon. Most second malignancies are solid tumors or other lymphoproliferative proliferative disorders. In this study, a case of a tartrate-resistant acid phosphatase (TRAP)-positive hairy cell leukemia variant with the subsequent development of Philadelphia chromosome-positive chronic myelogenous leukemia (CML) is reported.<bold>Methods: </bold>Routine morphology was performed on the peripheral blood, bone marrow and spleen. Peripheral smears were stained for TRAP. Peripheral blood was studied by two-color flow cytometry for a panel of lymphocytic markers including CD11, CD25, and CD103. Cytogenetic studies were performed on a bone marrow aspirate.<bold>Results: </bold>A unique case of a hairy cell leukemia variant and CML in a patient who responded to the new purine analog 2-chlorodeoxyadenosine (2-CdA) is presented.<bold>Conclusions: </bold>The first case of concurrent hairy cell leukemia with CML is reported.
- Publication
Cancer (0008543X), 1995, Vol 75, Issue 8, p2089
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19950415)75:8<2089::AID-CNCR2820750810>3.0.CO;2-P