We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Type 2 Vaccine-Derived Poliovirus from Patients with Acute Flaccid Paralysis in China: Current Immunization Strategy Effectively Prevented Its Sustained Transmission.
- Authors
Yong Zhang; Dongmei Yan; Shuangli Zhu; Ning Wen; Li Li; Haiyan Wang; Jianfeng Liu; Xufang Ye; Zhengrong Ding; Dongyan Wang; Hui Zhu; Li Chen; Xiaohui Hou; Hongqiu An; Xiaofeng Liang; Huiming Luo; Kew, Olen; Wenbo Xu
- Abstract
In China, 5 patients with acute flaccid paralysis (AFP) associated with type 2 vaccine-derived poliovirus (VDPV) were identified by an AFP surveillance system from 1996 through 2009. A maximum-likelihood tree shows that all 5 Chinese VDPVs were independent. These 5 VDPVs were 100-216 d old according to the number of synonymous substitutions per synonymous site and 176-292 d old according to the number of substitutions per site. This result indicates limited virus replication since the administration of the initiating oral polio vaccine (OPV) dose, which is consistent with the rapid evolution rate of poliovirus genomes. The abovementioned VDPVs have important implications in the global polio eradication initiative. Localized, limited, and transient circulation may be typical of OPVs; hence, independent VDPVs could be found because of the large population and excellent surveillance system, which permitted early detection and response, but sustained transmission was limited because of high population immunity.
- Subjects
CHINA; FLACCID dysarthria; IMMUNIZATION; PREVENTION of infectious disease transmission; POLIOMYELITIS vaccines; VIRUS-induced immunosuppression
- Publication
Journal of Infectious Diseases, 2010, Vol 202, Issue 12, p1780
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/657410