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- Title
Review of Rotavirus Studies in Africa: 1976-2006.
- Authors
Waggie, Zainab; Hawkridge, Anthony; Hussey, Gregory D.
- Abstract
Background. Rotavirus is a common cause of severe diarrhea! disease in children worldwide. Ninety percent of the associated deaths occur in sub-Saharan Africa and South East Asia, Our aim was to review the prevalence of rotavirus infection in Africa over the past 30 years. Methods. Eligible studies were identified from 3 Medline searches. Only studies including children <5 years of age that included >50 children and had an observational period >3 months were included. The data were analyzed during 3 periods (1976-1985, 1986-1995, and 1996-2006), as a summary (1976-2006), and by different study settings (ie, hospital, outpatient department, and combined). Results. The initial search identified 206 studies from 27 countries during 1976-2006. The refined search yielded 101 studies, of which 58 (57%) were hospital based, 25 (25%) were outpatient studies, and 18 (18%) were combined. Rotavirus was detected in 25% (interquartile range, 16%-32%) of stool samples. Rotavirus was the most common agent identified in 73% of studies in which multiple diarrhea! agents were determined. Conclusion. Rotavirus is an important cause of severe diarrhea! disease in children <5 years of age in Africa. Clinical trials in South Africa and Malawi have shown that severe rotavirus disease is a vaccine-preventable entity in Africa.
- Subjects
AFRICA; ROTAVIRUSES; ROTAVIRUS diseases; DIARRHEA in children; CHILDREN'S health; EPIDEMIOLOGY
- Publication
Journal of Infectious Diseases, 2010, Vol 202, pS23
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/653554