We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The Virologic and Immunologic Effects of Cyclosporine as an Adjunct to Antiretroviral Therapy in Patients Treated during Acute and Early HIV-1 Infection.
- Authors
Markowitz, Martin; Vaida, Florin; Hare, C. Bradley; Boden, Daniel; Mohri, Hiroshi; Hecht, Frederick M.; Kalayjian, Robert C.; Conrad, Ann; Mildvan, Donna; Aberg, Judith; Hogan, Christine; Kilby, J. Michael; Balfour Jr., Henry H.; Schafer, Kim; Richman, Douglas; Little, Susan
- Abstract
Acute human immunodeficiency virus type 1 (HIV-1) infection is characterized by high levels of immune activation. Immunomodulation with cyclosporine combined with antiretroviral therapy (ART) in the setting of acute and early HIV-1 infection has been reported to result in enhanced immune reconstitution. Fifty-four individuals with acute and early infection were randomized to receive ART with 4 weeks of cyclosporine versus ART alone. In 48 subjects who completed the study, there were no significant differences between treatment arms in levels of proviral DNA or CD4+ T cell counts. Adjunctive therapy with cyclosporine in this setting does not provide apparent virologic or immunologic benefit.
- Subjects
CYCLOSPORINE; ANTIRETROVIRAL agents; HIV infections; HIV-positive persons; HIV; IMMUNOREGULATION; T cells; DNA; THERAPEUTICS
- Publication
Journal of Infectious Diseases, 2010, Vol 201, Issue 9, p1298
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/651664