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- Title
Pre- and Postexposure Use of Human Monoclonal Antibody against H5N1 and H1N1 Influenza Virus in Mice: Viable Alternative to Oseltamivir.
- Authors
Koudstaal, Wouter; Koldijk, Martin H.; Brakenhoff, Just P. J.; Cornelissen, Lisette A. H. M.; Weverling, Gerrit Jan; Friesen, Robert H. E.; Goudsmit, Jaap
- Abstract
New strategies to prevent and treat influenza virus infections are urgently needed. A recently discovered class of monoclonal antibodies (mAbs) neutralizing an unprecedented spectrum of influenza virus subtypes may have the potential for future use in humans. Here, we assess the efficacies of CR6261, which is representative of this novel class of mAbs, and oseltamivir in mice. We show that a single injection with 15 mg/kg CR6261 outperforms a 5-day course of treatment with oseltamivir (10 mg/kg/day) with respect to both prophylaxis and treatment of lethal H5N1 and H1N1 infections. These results justify further preclinical evaluation of broadly neutralizing mAbs against influenza virus for the prevention and treatment of influenza virus infections.
- Subjects
MONOCLONAL antibodies; H1N1 influenza; H5N1 Influenza; LABORATORY mice; MICROBIAL virulence; INJECTIONS; DENTAL prophylaxis; IMMUNOGLOBULINS
- Publication
Journal of Infectious Diseases, 2009, Vol 200, Issue 12, p1870
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/648378