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- Title
Persistence of Kaposi Sarcoma-- Associated Herpesvirus (KSHV)-- Infected Cells in KSHV/HIV-1-- Coinfected Subjects without KSHV-Associated Diseases.
- Authors
Campbell, Thomas B.; Staskus, Katherine A.; Folkvord, Joy; White, Irene E.; Neid, James; Xing-quan Zhang; Connick, Elizabeth
- Abstract
Inguinal lymph nodes from 24 human immunodeficiency virus (HIV) type 1-infected subjects without Kaposi sarcoma-associated herpesvints (KSHV)-associated diseases were examined for KSHV infection. KSHV-infected cells were detected at a very low frequency in the lymph nodes of 7 subjects (median frequency, 2 infected cells/107 lymph node cells). Latent, but not lytic, KSHV gene expression was detected and KSHV-infected cells were located in B cell-rich areas of lymph node follicles. These findings provide evidence that, in the absence of KSHV-associated diseases, latent infection of lymph node cells provides a mechanism for the persistence of KSHV in KSHV/HIV-1-coinfected persons.
- Subjects
IMMUNODEFICIENCY; KAPOSI'S sarcoma; HIV infections; GENE expression; GENETIC regulation; B cells; LYMPH nodes
- Publication
Journal of Infectious Diseases, 2005, Vol 191, Issue 3, p367
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/427194