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- Title
Role of Bacteriophage MAV1 as a Mycoplasmal Virulence Factor for the Development of Arthritis in Mice and Rats.
- Authors
Tu, Anh-Hue T.; Lindsey, J. Russell; Schoeb, Trenton R.; Elgavish, Ada; Yu, Huilan; Dybvig, Kevin
- Abstract
The lysogenic bacteriophage MAV1 has been shown to be a virulence factor for the development of arthritis in rats infected with Mycoplasma arthritidis. In the present study, arthritis was evaluated by histopathologic examination to demonstrate that MAV1 is a virulence factor not only in the rat but also in the mouse. Specifically, the MAV1 lysogen 158L3-1 was more virulent than the nonlysogen strain 158 in DBA/2NCr, C3H/HeNCr, C3H/HeJ, and C3Smn. CB17-Prkdc[sup scid]/J mice, as well as in LEW rats.
- Subjects
BACTERIOPHAGES; ARTHRITIS in animals; MICROBIAL virulence
- Publication
Journal of Infectious Diseases, 2002, Vol 186, Issue 3, p432
- ISSN
0022-1899
- Publication type
Article