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- Title
Chronic lymphocytic leukemia with plasmacytic differentiation.
- Authors
Lyapichev, Kirill A.; Kurt, Habibe; Sukswai, Narittee; Konoplev, Sergej; Bueso-Ramos, Carlos E.; Khoury, Joseph D.; Huh, Yang O.
- Abstract
Interestingly, in addition to lymphoma cells, occasional large round cells with eosinophilic globular cytoplasmic inclusions were noted (Fig. Although earlier it was demonstrated that differentiation of CLL cells into immunoglobulin-secreting (plasmacytoid) cells can lead to a decrease in LEF-1 expression, in our case we still can appreciate the positive staining in the neoplastic cells [[2]]. Similar phenotype with the same immunoglobulin light chain restriction and LEF-1 staining suggested that CLL cells and plasmacytoid cells are clonally related.
- Subjects
CHRONIC lymphocytic leukemia; WALDENSTROM'S macroglobulinemia; HODGKIN'S disease; B cells; BIOPSY; BONE marrow; CELL differentiation
- Publication
Annals of Hematology, 2019, Vol 98, Issue 10, p2437
- ISSN
0939-5555
- Publication type
case study
- DOI
10.1007/s00277-019-03784-x