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- Title
Levodopa induces dyskinesias in normal squirrel monkeys.
- Authors
Togasaki, Daniel M.; Tan, Louis; Protell, Peter; Di Monte, Donato A.; Quik, Maryka; Langston, J. William; Togasaki, D M; Tan, L; Protell, P; Di Monte, D A; Quik, M; Langston, J W
- Abstract
This study assessed whether or not levodopa induces dyskinesias in normal (ie, unlesioned) squirrel monkeys. All six animals treated twice daily with levodopa (15 mg/kg with carbidopa by oral gavage) for two weeks developed choreoathetoid dyskinesias, whereas none of the vehicle-treated animals displayed any abnormal movements. These dyskinesias did not merely reflect a generalized motor activation as locomotion was actually suppressed. The present data demonstrate that preexisting nigrostriatal damage is not necessary for the development of levodopa-induced dyskinesias.
- Publication
Annals of Neurology, 2001, Vol 50, Issue 2, p254
- ISSN
0364-5134
- Publication type
journal article
- DOI
10.1002/ana.1099