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- Title
DNA-catalyzed hydrolysis of DNA phosphodiesters.
- Authors
Fekry, Mostafa I.; Gates, Kent S.
- Abstract
The article reports on the findings of the study which describes DNA catalysts that effectively carry out sequence-specific hydrolysis of DNA phosphodiesters. The study identifies hydrolysis of the phosphodiester linkages in DNA as a difficult reaction. Moreover, it shows that deoxyribozymes, short segments of DNA capable of catalyzing chemical reactions, use Zn2+ and Mn2+ ions to accelerate DNA hydrolysis reaction by a factor of more than one hundred million.
- Subjects
DNA synthesis; CHEMICAL reactions; REACTION mechanisms (Chemistry); CHEMICAL processes; CATALYST supports; PHOSPHODIESTERS; HYDROLYSIS
- Publication
Nature Chemical Biology, 2009, Vol 5, Issue 10, p710
- ISSN
1552-4450
- Publication type
Article
- DOI
10.1038/nchembio.224