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- Title
Fanconi anemia and hematopoietic stem cell transplant as risk factors for oral squamous cell carcinoma: A case report with a 12‐year follow‐up.
- Authors
Macedo, Larissa Fernanda dos Santos Lima; Domaneschi, Carina; Miguita Luiz, Lucyene; Peres, Maria Paula Siqueira de Melo; Franco, Juliana Bertoldi
- Abstract
Fanconi anemia is a rare disorder resulting from defects in genes responsible for DNA damage responses. It is characterized by congenital anomalies, aplastic anemia, and a predisposition to cancer. Currently, hematopoietic stem cell transplant (HSCT) is the only curative treatment available for bone marrow failure; however, HSCT increases oral squamous cell carcinoma (OSCC) risk. Here we report the case of a patient diagnosed with Fanconi anemia in childhood who was treated with HSCT and later diagnosed with multiple OSCCs during a 12‐year follow‐up. Despite multiple surgical interventions and radiotherapy regimens, the patient's health deteriorated. Management of individuals with Fanconi anemia is challenging and must be provided by a multidisciplinary healthcare team to ensure better staging, treatment planning, and coordination.
- Subjects
FANCONI'S anemia; STEM cell transplantation; HEMATOPOIETIC stem cells; SQUAMOUS cell carcinoma; APLASTIC anemia
- Publication
Special Care in Dentistry, 2022, Vol 42, Issue 3, p299
- ISSN
0275-1879
- Publication type
Article
- DOI
10.1111/scd.12668