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- Title
Balancing Early Aggression Against Risk of Progression in Multiple Sclerosis.
- Authors
Duquette, Pierre; Giacomini, Paul S.; Bhan, Virender; Hohol, Marika; Schecter, Robyn
- Abstract
Multiple sclerosis is a chronic demyelinating disease characterized by focal and diffuse inflammation of the central nervous system resulting in significant physical and cognitive disabilities. Disease-modifying therapies targeting the dysfunctional immune response are most effective in the first few years after disease onset, indicating that there is a limited time window for therapy to influence the disease course. No evidence of disease activity is emerging as a new standard for treatment response and may be associated with improved long-term disability outcomes. An aggressive management strategy, including earlier use of more potent immunomodulatory agents and close monitoring of the clinical and radiologic response to treatment, is recommended to minimize early brain volume loss and slow the progression of physical and cognitive impairments in patients with relapsing-remitting multiple sclerosis.
- Subjects
MULTIPLE sclerosis; DISEASE progression; IMMUNOLOGICAL adjuvants; MYELIN sheath diseases; DEMYELINATION; DISEASE risk factors
- Publication
Canadian Journal of Neurological Sciences, 2016, Vol 43, Issue 1, p33
- ISSN
0317-1671
- Publication type
Article
- DOI
10.1017/cjn.2015.302