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- Title
ARHGAP42 rs604723 Gene Polymorphism Is Associated With Pulse Wave Speed In Hypertension Diagnosed Subjects.
- Authors
KOSOVA, Buket; KARA, Hale GÜLER; SOYDAN, Elton; JAFARI, Duygu Döndü AYGÜNEŞ; VARDARLI, Aslı TETİK; ATAY, Gökhan; ÖZKAHYA, Mehmet; BOZOK, Vildan; DEMİRCİ, Meltem SEZİŞ
- Abstract
Background: Hypertension is a systemic disease characterized by high blood pressure and an important threat for the population, as it is common and can cause serious complications. Genetic and environmental factors are involved in its development like the recently defined genetic risk factor ARHGAP42 that encodes the Rho GTPase activating protein 42. In this study, the intronic rs604723 (C/T) gene polymorphism of ARHGAP42 was investigated in relation to arterial stiffness. Materials and Methods: Peripheral blood samples, taken from 63 study group subjects with hypertension and 100 healthy subjects as control, were analyzed for the presence of the ARHGAP42 rs604723 gene polymorphism by a real-time PCR method following DNA isolation. Demographic data of the study group subjects were recorded and blood pressure, ambulatory blood pressure and arterial stiffness values were measured. Results: The heterozygous polymorphic CT (-2-fold) and homozygous polymorphic TT (-1.6-fold) genotypes were found to be higher in study group subjects when compared to the control group subjects, whereby the increase of the CT genotype was statistically significant (p = 0.002). Similarly, the frequency of the polymorphic T allele was found to be higher (-1.9-fold) and statistically significant (p = 0.003) in the study group subjects. In addition, the heterozygous polymorphic CT and homozygous polymorphic TT genotypes were determined to be associated with carotid-femoral pulse velocity, which is a measure of arterial stiffness (p = 0.025). Conclusions: In this study, the ARHGAP42 rs604723 (C/T) gene polymorphism was found to be associated with pulse wave speed in subjects with hypertension. It will be of interest, to investigate its association with any specific drug or drugs commonly used in anti-hypertensive therapy. Thus, it would be possible to select the appropriate drug or drugs according to the hypertensive subjects' genotype to carry out personalized medicine in future.
- Subjects
HYPERTENSION risk factors; RISK assessment; ARTERIAL diseases; RESEARCH funding; QUESTIONNAIRES; GENETIC polymorphisms; GENE expression; PULSE wave analysis; BLOOD pressure; VASCULAR diseases
- Publication
Journal of Harran University Medical Faculty / Harran Üniversitesi Tıp Fakültesi Dergisi, 2024, Vol 21, Issue 2, p271
- ISSN
1304-9623
- Publication type
Article
- DOI
10.35440/hutfd.1424247