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- Title
Weekly Journal Scan: a novel RNA-based approach to the treatment of hypertriglyceridaemia.
- Authors
Galiuto, Leonarda; Volpe, Massimo
- Abstract
A Phase 2b trial funded by the industry tested the efficacy and safety of olezarsen, an RNA-based treatment, in patients with moderate or severe hypertriglyceridemia and elevated cardiovascular risk. Patients were randomly assigned to receive either 50 or 80 mg of olezarsen or a placebo once a month for 12 months. The primary outcome was the percentage change in plasma triglyceride levels from baseline to 6 months. At 6 months, both doses of olezarsen significantly reduced triglyceride levels compared to the placebo group. Adverse events were comparable among the three groups, with only a few cases requiring drug discontinuation. Further studies are needed to assess the long-term efficacy and safety of olezarsen.
- Subjects
LDL cholesterol; HEART disease diagnosis; SMALL interfering RNA; APOLIPOPROTEIN C; OMEGA-3 fatty acids; ATHEROSCLEROTIC plaque
- Publication
European Heart Journal, 2024, Vol 45, Issue 33, p3016
- ISSN
0195-668X
- Publication type
Article
- DOI
10.1093/eurheartj/ehae351