We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effect of a Triterpenoid-Rich Olive Oil on Chronic Kidney Disease in an Experimental Model of Diabetes Mellitus.
- Authors
De La Cruz, José Pedro; Osuna-Esteban, Laura; Rodríguez-Pérez, María Dolores; Ortega-Hombrados, Laura; Sánchez-Tévar, Ana María; Martín-Aurioles, Esther; Fernández-Prior, María África; Pérez-Burillo, Sergio; Espejo-Calvo, Juan Antonio; González-Correa, José Antonio
- Abstract
The aim of this study was to assess the effect of triterpenoids on the development of diabetic nephropathy in an experimental model of diabetes mellitus. For this purpose, a destoned and dehydrated olive oil (DDOO) was used, comparing its effects to a destoned olive oil (DOO). DDOO had a higher triterpenoid content than DOO but an equal content of alcoholic polyphenols. Four study groups (n = 10 animals/group) were formed: healthy rats, diabetic control rats (DRs), and DRs treated orally with 0.5 mL/kg/day of DOO or DDOO for two months. DRs showed impaired renal function (proteinuria, increased serum creatinine, decreased renal creatinine clearance) and morphology (glomerular volume and glomerulosclerosis). These alterations correlated with increased systemic and renal tissue oxidative stress and decreased prostacyclin production. DDOO administration significantly reduced all variables of renal damage, as well as systemic and renal oxidative stress, to a greater extent than the effect produced by DOO. In conclusion, triterpenoid-rich olive oil may prevent kidney damage in experimental diabetes mellitus.
- Subjects
DIABETES complications; THERAPEUTIC use of olive oil; KIDNEY disease prevention; PROSTACYCLIN; CREATININE; RESEARCH funding; DIABETIC nephropathies; TERPENES; OXIDATIVE stress; TREATMENT effectiveness; DESCRIPTIVE statistics; CHRONIC kidney failure; EXPERIMENTAL design; RATS; ANIMAL experimentation; STATISTICS; ANALYSIS of variance; DATA analysis software; POLYPHENOLS
- Publication
Nutrients, 2024, Vol 16, Issue 16, p2794
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16162794