We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Continuous versus intermittent administration of piperacillin-tazobactam in intensive care unit patients with ventilator-associated pneumonia.
- Authors
Fahimi, Fanak; Ghafari, Somayeh; Jamaati, Hamidreza; Baniasadi, Shadi; Tabarsi, Payam; Najafi, Arvin; Akhzarmehr, Arnavaz; Hashemian, Seyed Mohammad Reza
- Abstract
Background and Aims: Ventilator-associated pneumonia (VAP) is one of the most common Intensive Care Unit (ICU)-acquired infection. The aim of this study was to compare the clinical outcome of continuous and intermittent administration of piperacillin- tazobactam by serial measurements of the Clinical Pulmonary Infection Score (CPIS). Subjects and Methods: Groups were designed as parallel and the study was designed as quasi-experimental and conducted at a semi-closed ICU between September 2008 and May 2010. Patients received 3.375 g (piperacillin 3 g/tazobactam 0.375 g) either through intermittent infusion every 6 h for 30 min [Intermittent Infusion (II) group; n = 30] or through continuous infusion every 8 h for 4 h [Continuous Infusion (CI) group; n = 31]. CPIS was used to assess the clinical diagnosis and outcome of VAP patients. Results: Sex, age, Acute Physiology and Chronic Health Evaluation II II score on ICU admission, diagnosis and underlying disease of VAP patients were not significantly different in the CI (n = 31) and II (n = 30) groups. Duration of mechanical ventilation, length of stay, total number of antibiotics used per patient and duration of piperacillin/tazobactam treatment were similar in both groups. Mortality rates of VAP patients were similar between both groups during hospitalization. Conclusion: There was no significant difference in clinical outcomes of patients receiving piperacillin-tazobactam via CI or II when measured by serial CPIS score.
- Subjects
EVALUATION of medical care; ANTI-infective agents; ANTIBIOTICS; DRUG therapy; CHI-squared test; FISHER exact test; INTENSIVE care units; RESEARCH methodology; PNEUMONIA; T-test (Statistics); TIME; U-statistics; MECHANICAL ventilators; AMPICILLIN; DATA analysis software
- Publication
Indian Journal of Critical Care Medicine, 2012, Vol 16, Issue 3, p141
- ISSN
0972-5229
- Publication type
Article
- DOI
10.4103/0972-5229.102083