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- Title
Oxidized Low Density Lipoprotein and Inflammation in Gout Patients.
- Authors
Jiang, Xingliang; Li, Min; Yang, Qibin; Du, Lijun; Du, Juan; Zhou, Jingguo
- Abstract
To analyze the levels of oxidized low density lipoprotein (ox-LDL) and inflammatory cytokines in the plasma of gout patients. The levels of ox-LDL, hypersensitive C-reactive protein (hs-CRP), interleukin-1β, interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were measured in the plasma of 41 gout patients [28 in acute phase episode, 13 in intermittent phase (IP)], and in 40 healthy controls. The relationship between ox-LDL and inflammation was also explored by measuring the levels of several pro-inflammatory cytokines in the plasma. The plasma levels of ox-LDL, hs-CRP, IL-6 and TNF-α were significantly increased in patients with gout in the acute phase compared to those in the IP group and healthy controls ( P < 0.05), but the levels of TGF-β were significantly lower in the acute phase group than in the IP group and healthy controls ( P < 0.01). The levels of ox-LDL in the gout patients in the IP were significantly higher than those in healthy controls ( P < 0.05). Correlation analysis indicated that the levels of ox-LDL were positively correlated with hs-CRP, IL-6 and TNF-α ( r = 0.343, r = 0.386, r = 0.659, P < 0.01, respectively), but negatively correlated with TGF-β levels in patients in the acute phase ( r = −0.240, P < 0.05). The levels of ox-LDL in gout patients were significantly higher than those in healthy controls. The changes in ox-LDL levels may be associated with enhanced inflammation in gout patients.
- Subjects
LOW density lipoproteins; INFLAMMATION; GOUT; CYTOKINES; TUMOR necrosis factors; C-reactive protein; PATIENTS
- Publication
Cell Biochemistry & Biophysics, 2014, Vol 69, Issue 1, p65
- ISSN
1085-9195
- Publication type
Article
- DOI
10.1007/s12013-013-9767-5