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- Title
Organ Metallome Processed with Chemometric Methods Enable the Determination of Elements that May Serve as Markers of Exposure to Iron Oxide Nanoparticles in Male Rats.
- Authors
Rugiel, Marzena; Drozdz, Agnieszka; Matusiak, Katarzyna; Setkowicz, Zuzanna; Klodowski, Krzysztof; Chwiej, Joanna
- Abstract
The systemic influence of iron oxide nanoparticles on the elemental homeostasis of key organs was examined in male rats. In tissues taken at different intervals from nanoparticles injection, the dynamics of elemental changes was analyzed. The organ metallome was studied using total reflection X-ray fluorescence. The obtained data were processed with advanced cluster and discriminant analyses—to classify the tissues according to their organs of origin and to distinguish accurately the nanoparticle-treated and normal rats. Additionally, in the case of liver and heart, it was possible to determine the elements of highest significance for different treatments, which may serve as markers of exposure to iron oxide nanoparticles.
- Subjects
CLUSTER analysis (Statistics); X-ray fluorescence; IRON oxide nanoparticles; X-ray reflection; DISCRIMINANT analysis; RATS; IRON oxides
- Publication
Biological Trace Element Research, 2020, Vol 198, Issue 2, p602
- ISSN
0163-4984
- Publication type
Article
- DOI
10.1007/s12011-020-02104-z