We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Extravasation reactions associated with the administration of pamidronate: 11 cases (2008-2013).
- Authors
Marker, B. A.; Barber, L. G.; Clifford, C. A.; Correa, S. S.; Thalhofer, P. L.; LaDue, T. A.; Mullin, C. M.; Sauerbrey, M. L.; Wood, C. C.
- Abstract
Pamidronate is a bisphosphonate drug widely utilized in veterinary oncologic practice for the palliation of malignant osteolysis. Pamidronate has not been previously reported to cause tissue injury upon extravasation in dogs. The medical records of 11 client-owned dogs undergoing palliative treatment for primary bone tumors with known or suspected pamidronate extravasation reactions were reviewed. The majority of adverse events were low grade in nature, however in some cases, the reactions were severe and led to euthanasia in one instance. Time to complete resolution of lesions ranged from within several days to greater than one and a half months. Aside from the dog that was euthanized, no long-term sequelae of extravasation were identified. Treatments employed to address the reactions varied widely. Pamidronate extravasation reaction appears to be an uncommon, but potentially serious complication of intravenous administration.
- Subjects
DISODIUM pamidronate; BONE resorption; TISSUE wounds; EXTRAVASATION; BONE cancer
- Publication
Veterinary & Comparative Oncology, 2017, Vol 15, Issue 2, p470
- ISSN
1476-5810
- Publication type
Article
- DOI
10.1111/vco.12191