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- Title
Chitosan Based Diamond Paste Stochastic Microsensors Modified with Gold Nanoparticles Detect Hepatitis C Virus Core Antigen.
- Authors
Moldoveanu, Iuliana; Stefan‐van Staden, Raluca‐Ioana; Frederick van Staden, Jacobus
- Abstract
Three types of chitosan (chitosan I ( n=371-744), chitosan II ( n=682-930), and chitosan III ( n=868-1365)) as well as gold nanoparticles (10 nm diameter) were used to modify diamond paste for the design of new stochastic microsensors. Hepatitis C virus core antigen was used as model analyte to prove the stochastic behavior of the proposed microsensors. The microsensors cover a linear range of concentration between 40 fg/mL and 4 ng/mL. The highest sensitivity (1.38×105 s−1/mg/mL) and the lower limit of determination (40 fg/mL) were obtained for chitosan III based microsensor. The hepatitis C virus core antigen was assayed from whole blood samples with recoveries higher than 98.00 %.
- Subjects
CHITOSAN; GOLD nanoparticles; DIAMONDS; MICROSENSORS; MACHINE design; VIRAL antigens; HEPATITIS C virus
- Publication
Electroanalysis, 2015, Vol 27, Issue 8, p1842
- ISSN
1040-0397
- Publication type
Article
- DOI
10.1002/elan.201500081