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- Title
An ITO Based Disposable Biosensor for Ultrasensitive Analysis of Retinol Binding Protein.
- Authors
Şimşek, Çiğdem Sayıklı; Teke, Mustafa; Sezgintürk, Mustafa Kemal
- Abstract
A highly sensitive electrochemical biosensor based on anti-RBP biorecognition capable to analyze concentrations of retinol binding protein (RBP) was developed. The construction of the biosensor interfaces was carefully characterized by techniques such as electrochemistry, EIS, and scanning electron microscopy. In order to characterize impedance data, Kramers-Kronig Transform was performed on the experimental impedance data. Besides, for an immunosensor system the Single Frequency Impedance technique was firstly used for the characterization of the interaction between RBP and anti-RBP. Finally, artificial serum samples spiked with RBP were analyzed by the proposed ITO based immunosensor to investigate the usefulness of the biosensor for early biomarker diagnosis.
- Subjects
RETINOL-binding proteins; BIOSENSORS; SCANNING electron microscopy; BIOMARKERS; ELECTRIC impedance
- Publication
Electroanalysis, 2014, Vol 26, Issue 2, p328
- ISSN
1040-0397
- Publication type
Article
- DOI
10.1002/elan.201300443