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- Title
Total Synthesis of the Diterpenoid (+)-Harringtonolide.
- Authors
Zhang, Hai ‐ Jun; Hu, Lin; Ma, Zhiqiang; Li, Ruining; Zhang, Zhen; Tao, Cheng; Cheng, Bin; Li, Yun; Wang, Huifei; Zhai, Hongbin
- Abstract
Described herein is the first asymmetric total synthesis of (+)-harringtonolide, a natural diterpenoid with an unusual tropone imbedded in a cagelike framework. The key transformations include an intramolecular Diels-Alder reaction and a rhodium-complex-catalyzed intramolecular [3+2] cycloaddition to install the tetracyclic core as well as a highly efficient tropone formation.
- Subjects
ASYMMETRIC synthesis; DITERPENES; DIELS-Alder reaction; RHODIUM catalysts; RING formation (Chemistry); TROPONES
- Publication
Angewandte Chemie, 2016, Vol 128, Issue 38, p11810
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201605879