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- Title
H<sub>2</sub>-Fueled ATP Synthesis on an Electrode: Mimicking Cellular Respiration.
- Authors
Gutiérrez ‐ Sanz, Óscar; Natale, Paolo; Márquez, Ileana; Marques, Marta C.; Zacarias, Sonia; Pita, Marcos; Pereira, Inês A. C.; López ‐ Montero, Iván; De Lacey, Antonio L.; Vélez, Marisela
- Abstract
ATP, the molecule used by living organisms to supply energy to many different metabolic processes, is synthesized mostly by the ATPase synthase using a proton or sodium gradient generated across a lipid membrane. We present evidence that a modified electrode surface integrating a NiFeSe hydrogenase and a F1F0-ATPase in a lipid membrane can couple the electrochemical oxidation of H2 to the synthesis of ATP. This electrode-assisted conversion of H2 gas into ATP could serve to generate this biochemical fuel locally when required in biomedical devices or enzymatic synthesis of valuable products.
- Subjects
ELECTRODES; CELL respiration; CELL metabolism; ADENOSINE triphosphatase; BILAYER lipid membranes
- Publication
Angewandte Chemie, 2016, Vol 128, Issue 21, p6324
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201600752