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- Title
Screening of Omicron Virus Strain by Quantifying the Spike Protein Content.
- Authors
He, Zhenyu; Chang, Hengzhen; Wang, Yichuan; Xie, Siman; Liu, Yingwei; Zhao, Yuxiu; Li, Na; Zhang, Yuntao
- Abstract
In the development of an inactivated virus vaccine, the isolation of a single virus strain plays a key role in determining potency. The conventional methods of quantification of virus number are mainly based on virus titers, which are subjective and time-consuming, especially in the early stage of virus isolation, in which the titer difference is weak. Previous reports have shown a high correlation between the spike protein and the potency of COVID-19 vaccines. In this paper, we report a novel, fast, and convenient method of screening an Omicron virus strain by quantifying the spike protein content, where the isolated strain shows high affinity to Omicron-specific antibodies and a high titer, and it can induce high levels of neutralization antibodies.
- Subjects
SARS-CoV-2 Omicron variant; CORONAVIRUS spike protein; COVID-19 pandemic; PUBLIC health; COVID-19 vaccines
- Publication
COVID, 2024, Vol 4, Issue 6, p838
- ISSN
2673-8112
- Publication type
Article
- DOI
10.3390/covid4060056