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- Title
Recent trends of capillary electrophoresis‐mass spectrometry in proteomics research.
- Authors
Gomes, Fabio P.; Yates, John R.
- Abstract
Progress in proteomics research has led to a demand for powerful analytical tools with high separation efficiency and sensitivity for confident identification and quantification of proteins, posttranslational modifications, and protein complexes expressed in cells and tissues. This demand has significantly increased interest in capillary electrophoresis‐mass spectrometry (CE‐MS) in the past few years. This review provides highlights of recent advances in CE‐MS for proteomics research, including a short introduction to top‐down mass spectrometry and native mass spectrometry (native MS), as well as a detailed overview of CE methods. Both the potential and limitations of these methods for the analysis of proteins and peptides in synthetic and biological samples and the challenges of CE methods are discussed, along with perspectives about the future direction of CE‐MS. @ 2019 Wiley Periodicals, Inc. Mass Spec Rev 00:1–16, 2019.
- Subjects
TANDEM mass spectrometry; CAPILLARY electrophoresis; SPECTROMETRY; CROSS-entropy method; POST-translational modification; PEPTIDOMIMETICS
- Publication
Mass Spectrometry Reviews, 2019, Vol 38, Issue 6, p445
- ISSN
0277-7037
- Publication type
Article
- DOI
10.1002/mas.21599